Folding Rate of Protein and RNA Studied from Quantum Folding Theory
نویسندگان
چکیده
Starting from the assumption that the protein and RNA folding is an event of quantum transition between molecular conformations,we deduced a folding rate formula and studied the chain length (torsion number) dependence and temperature dependence of the folding rate. The chain length dependence of the folding rate was tested in 65 two-state proteins and 27 RNA molecules. The success of the comparative study of protein and RNA folding reveals the possible existence of a common quantum mechanism in the conformational change of biomolecules. The predicted temperature dependence of the folding rate has also been successfully tested for proteins. Its further test in RNA is expected.
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